Ontology highlight
ABSTRACT:
SUBMITTER: Thullen SM
PROVIDER: S-EPMC7097885 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Thullen Scott M SM Treacy Sean M SM Rovis Tomislav T
Journal of the American Chemical Society 20190903 36
The functionalization of unactivated C(<i>sp</i><sup>3</sup>)-H bonds poses a significant challenge due to their ubiquity and relative similarity in most organic frameworks. Herein, we describe the use of a combined photoredox and nickel catalytic system for the regioselective C(<i>sp</i><sup>3</sup>)-C(<i>sp</i><sup>3</sup>) coupling of unactivated C(<i>sp</i><sup>3</sup>)-H bonds and alkyl bromides. Positional selectivity is dictated by a 1,5-hydrogen atom transfer (HAT) reaction by a pendent ...[more]