Dataset Information

The Effects of Random Stimulation Rate on Measurements of Auditory Brainstem Response.

ABSTRACT: Electroencephalography (EEG) signal is an electrophysiological recording from electrodes placed on the scalp to reflect the electrical activities of the brain. Auditory brainstem response (ABR) is one type of EEG signals in response to an auditory stimulus, and it has been widely used to evaluate the potential disorders of the auditory function within the brain. Currently, the ABR measurements in the clinic usually adopt a fixed stimulation rate (FSR) technique in which the late evoked response could contaminate the ABR signals and deteriorate the waveform differentiation after averaging, thus compromising the overall auditory function assessment task. To resolve this issue, this study proposed a random stimulation rate (RSR) method by integrating a random interval between two adjacent stimuli. The results showed that the proposed RSR method was consistently repeatable and reliable in multiple trials of repeated measurements, and there was a large amplitude of successive late evoked response that would contaminate the ABR signals for conventional FSR methods. The ABR waveforms of the RSR method showed better wave I-V morphology across different stimulation rates and stimulus levels, and the improved ABR morphology played an important role in early diagnoses of auditory pathway abnormities. The correlation coefficients as functions of averaging time showed that the ABR waveform of the RSR method stabilizes significantly faster, and therefore, it could be used to speed up current ABR measurements with more reliable testing results. The study suggests that the proposed method would potentially aid the adequate reconstruction of ABR signals towards a more effective means of hearing loss screening, brain function diagnoses, and potential brain-computer interface.

SUBMITTER: Wang X

PROVIDER: S-EPMC7098959 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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The Effects of Random Stimulation Rate on Measurements of Auditory Brainstem Response.

Wang Xin X Zhu Mingxing M Samuel Oluwarotimi Williams OW Wang Xiaochen X Zhang Haoshi H Yao Junjie J Lu Yun Y Wang Mingjiang M Mukhopadhyay Subhas Chandra SC Wu Wanqing W Chen Shixiong S Li Guanglin G

Frontiers in human neuroscience 20200320

Electroencephalography (EEG) signal is an electrophysiological recording from electrodes placed on the scalp to reflect the electrical activities of the brain. Auditory brainstem response (ABR) is one type of EEG signals in response to an auditory stimulus, and it has been widely used to evaluate the potential disorders of the auditory function within the brain. Currently, the ABR measurements in the clinic usually adopt a fixed stimulation rate (FSR) technique in which the late evoked response ...[more]

PMID: 32265673

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Project description:The auditory brainstem response (ABR) is an invaluable assay in clinical audiology, non-human animals, and human research. Despite the widespread use of ABRs in measuring auditory neural synchrony and estimating hearing sensitivity in other vertebrate model systems, methods for recording ABRs in the chicken have not been reported in nearly four decades. Chickens provide a robust animal research model because their auditory system is near functional maturation during late embryonic and early hatchling stages. We have demonstrated methods used to elicit one or two-channel ABR recordings using subdermal needle electrode arrays in chicken hatchlings. Regardless of electrode recording configuration (i.e., montage), ABR recordings included 3-4 positive-going peak waveforms within the first 6 ms of a suprathreshold click stimulus. Peak-to-trough waveform amplitudes ranged from 2-11 µV at high-intensity levels, with positive peaks exhibiting expected latency-intensity functions (i.e., increase in latency as a function of decreased intensity). Standardized earphone position was critical for optimal recordings as loose skin can occlude the ear canal, and animal movement can dislodge the stimulus transducer. Peak amplitudes were smaller, and latencies were longer as animal body temperature lowered, supporting the need for maintaining physiological body temperature. For young hatchlings (<3 h post-hatch day 1), thresholds were elevated by ~5 dB, peak latencies increased ~1-2 ms, and peak to trough amplitudes were decreased ~1 µV compared to older hatchlings. This suggests a potential conductive-related issue (i.e., fluid in the middle ear cavity) and should be considered for young hatchlings. Overall, the ABR methods outlined here permit accurate and reproducible recording of in-vivo auditory function in chicken hatchlings that could be applied to different stages of development. Such findings are easily compared to human and mammalian models of hearing loss, aging, or other auditory-related manipulations.

Project description:In human and animal auditory perception the perceived quality of sound streams changes depending on the duration of inter-sound intervals (ISIs). Here, we studied whether adaptation and the precision of temporal coding in the auditory periphery reproduce general perceptual boundaries in the time domain near 20, 100, and 400 ms ISIs, the physiological origin of which are unknown. In four experiments, we recorded auditory brainstem responses with five wave peaks (P1 -P5) in response to acoustic models of communication calls of house mice, who perceived these calls with the mentioned boundaries. The newly introduced measure of average standard deviations of wave latencies of individual animals indicate the waves' temporal precision (latency jitter) mostly in the range of 30-100 μs, very similar to latency jitter of single neurons. Adaptation effects of response latencies and latency jitter were measured for ISIs of 10-1000 ms. Adaptation decreased with increasing ISI duration following exponential or linear (on a logarithmic scale) functions in the range of up to about 200 ms ISIs. Adaptation effects were specific for each processing level in the auditory system. The perceptual boundaries near 20-30 and 100 ms ISIs were reflected in significant adaptation of latencies together with increases of latency jitter at P2-P5 for ISIs < ~30 ms and at P5 for ISIs < ~100 ms, respectively. Adaptation effects occurred when frequencies in a sound stream were within the same critical band. Ongoing low-frequency components/formants in a sound enhanced (decrease of latencies) coding of high-frequency components/formants when the frequencies concerned different critical bands. The results are discussed in the context of coding multi-harmonic sounds and stop-consonants-vowel pairs in the auditory brainstem. Furthermore, latency data at P1 (cochlea level) offer a reasonable value for the base-to-apex cochlear travel time in the mouse (0.342 ms) that has not been determined experimentally.

Project description:This cross-sectional study had two goals: (1) Identify and quantify the effects of aging on the auditory brainstem response (ABR); (2) Describe how click rate and hearing impairment modify effects of aging. RESEARCH DESIGN AND ANALYSIS: ABR measures were obtained from 131 predominately male Veteran participants aged 26 to 71 yr. Metrics analyzed include amplitude and latency for waves I, III, and V, and the I-V interpeak latency interval (IPI) at three repetition rates (11, 51, and 71 clicks/sec) using both polarities. In order to avoid confounding from missing data due to hearing impairment, participants had hearing thresholds <40 dB HL at 2 kHz and 70 dB HL at 4 kHz in at least one ear. Additionally, the median 2, 3, and 4 kHz pure tone threshold average (PTA2,3,4) for the sample, ∼17 dB HL, was used to delineate subgroups of better and worse hearing ears, and only the better hearing sample was modeled statistically. We modeled ABR responses using age, repetition rate, and PTA2,3,4 as covariates. Random effects were used to model correlation between the two ears of a subject and across repetition rates. Inferences regarding effects of aging on ABR measures at each rate were derived from the fitted model. Results were compared to data from subjects with poorer hearing.Aging substantially diminished amplitudes of all of the principal ABR peaks, largely independent of any threshold differences within the group. For waves I and III, age-related amplitude decrements were greatest at a low (11/sec) click rate. At the 11/sec rate, the model-based mean wave III amplitude was significantly smaller in older compared with younger subjects even after adjusting for wave I amplitude. Aging also increased ABR peak latencies, with significant shifts limited to early waves. The I-V IPI did not change with age. For both younger and older subjects, increasing click presentation rate significantly decreased amplitudes of early peaks and prolonged latencies of later peaks, resulting in increased IPIs. Advanced age did not enhance effects of rate. Instead, the rate effect on wave I and III amplitudes was attenuated for the older subjects due to reduced peak amplitudes at lower click rates. Compared with model predictions from the sample of better hearing subjects, mean ABR amplitudes were diminished in the group with poorer hearing, and wave V latencies were prolonged.In a sample of veterans, aging substantially reduced amplitudes of all principal ABR peaks, with significant latency shifts limited to waves I and III. Aging did not influence the I-V IPI even at high click rates, suggesting that the observed absolute latency changes associated with aging can be attributed to changes in auditory nerve input. In contrast, ABR amplitude changes with age are not adequately explained by changes in wave I. Results suggest that aging reduces the numbers and/or synchrony of contributing auditory nerve units. Results also support the concept that aging reduces the numbers, though perhaps not the synchrony, of central ABR generators.

Dataset Information

The Effects of Random Stimulation Rate on Measurements of Auditory Brainstem Response.

Publications

The Effects of Random Stimulation Rate on Measurements of Auditory Brainstem Response.

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