Ontology highlight
ABSTRACT:
SUBMITTER: Cao M
PROVIDER: S-EPMC7098961 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Cao Minyuan M Yin Dandan D Qin Yun Y Liao Fei F Su Yali Y Xia Xuyang X Gao Ju J Zhu Yiping Y Zhang Wei W Shu Yang Y Lu Xiaoxi X
Frontiers in pharmacology 20200320
A small proportion of patients with acute lymphoblastic leukemia (ALL) may experience severe leukopenia after treating with 6-mercaptopurine (6MP), which can be largely explained by germline variants in <i>TPMT</i> and <i>NUDT15</i>. However, a minority of patients who suffered such adverse drug reaction have <i>NUDT15</i> <sup>wt/wt</sup> <i>TPMT</i> <sup>wt/wt</sup> genotype, indicating that other genetic factors may take part in. In this study, we genotyped 539 exon-located nonsilent pharmaco ...[more]