Ontology highlight
ABSTRACT:
SUBMITTER: Xing P
PROVIDER: S-EPMC7099068 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Nature communications 20200326 1
Near-infrared (NIR) fluorescent probes are among the most attractive chemical tools for biomedical imaging. However, their in vivo applications are hindered by albumin binding, generating unspecific fluorescence that masks the specific signal from the analyte. Here, combining experimental and docking methods, we elucidate that the reason for this problem is an acceptor (A) group-mediated capture of the dyes into hydrophobic pockets of albumin. This pocket-capturing phenomenon commonly applies to ...[more]