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Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine.

ABSTRACT: A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. Here, we devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigens and adjuvants together with a tracelessly responsive linker-monomer. Peptide-based neoantigens with diverse sequences and structures could be copolymerized with molecular adjuvants to form PNEs of high loading capacity for vaccine delivery without adding any carriers. The redox-responsive PNEs with controlled molecular weights and sizes efficiently targeted and accumulated in draining lymph nodes and greatly promoted the antigen capture and cross-presentation by professional antigen presenting cells. Mice immunized with PNEs showed markedly enhanced antigen-specific T cell response and the protective immunity against the tumor cell challenge.

SUBMITTER: Wei L

PROVIDER: S-EPMC7099592 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine.

Wei Lixia L Zhao Yu Y Hu Xiaomeng X Tang Li L

ACS central science 20200203 3

A versatile and highly effective platform remains a major challenge in the development of personalized cancer vaccines. Here, we devised a redox-responsive polycondensate neoepitope (PNE) through a reversible polycondensation reaction of peptide neoantigens and adjuvants together with a tracelessly responsive linker-monomer. Peptide-based neoantigens with diverse sequences and structures could be copolymerized with molecular adjuvants to form PNEs of high loading capacity for vaccine delivery wi ...[more]

PMID: 32232140

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