Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma.
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ABSTRACT:
SUBMITTER: Noorani A
PROVIDER: S-EPMC7100916 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma.
Noorani Ayesha A Li Xiaodun X Goddard Martin M Crawte Jason J Alexandrov Ludmil B LB Secrier Maria M Eldridge Matthew D MD Bower Lawrence L Weaver Jamie J Lao-Sirieix Pierre P Martincorena Inigo I Debiram-Beecham Irene I Grehan Nicola N MacRae Shona S Malhotra Shalini S Miremadi Ahmad A Thomas Tabitha T Galbraith Sarah S Petersen Lorraine L Preston Stephen D SD Gilligan David D Hindmarsh Andrew A Hardwick Richard H RH Stratton Michael R MR Wedge David C DC Fitzgerald Rebecca C RC
Nature genetics 20200106 1
The poor outcomes in esophageal adenocarcinoma (EAC) prompted us to interrogate the pattern and timing of metastatic spread. Whole-genome sequencing and phylogenetic analysis of 388 samples across 18 individuals with EAC showed, in 90% of patients, that multiple subclones from the primary tumor spread very rapidly from the primary site to form multiple metastases, including lymph nodes and distant tissues-a mode of dissemination that we term 'clonal diaspora'. Metastatic subclones at autopsy wer ...[more]
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