Dlx1/2 mice have abnormal enteric nervous system function.
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ABSTRACT:
SUBMITTER: Wright CM
PROVIDER: S-EPMC7101142 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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Dlx1/2 mice have abnormal enteric nervous system function.
Wright Christina M CM Garifallou James P JP Schneider Sabine S Mentch Heather L HL Kothakapa Deepika R DR Maguire Beth A BA Heuckeroth Robert O RO
JCI insight 20200227 4
Decades ago, investigators reported that mice lacking DLX1 and DLX2, transcription factors expressed in the enteric nervous system (ENS), die with possible bowel motility problems. These problems were never fully elucidated. We found that mice lacking DLX1 and DLX2 (Dlx1/2-/- mice) had slower small bowel transit and reduced or absent neurally mediated contraction complexes. In contrast, small bowel motility seemed normal in adult mice lacking DLX1 (Dlx1-/-). Even with detailed anatomic studies, ...[more]
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