Ontology highlight
ABSTRACT:
SUBMITTER: Ohara Y
PROVIDER: S-EPMC7862435 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Ohara Yukiko Y Fujimura Lisa L Sakamoto Akemi A Teratake Youichi Y Hiraoka Shuichi S Koseki Haruhiko H Saito Takeshi T Terui Keita K Mitsunaga Tetsuya T Nakata Mitsuyuki M Yoshida Hideo H Hatano Masahiko M
Scientific reports 20210204 1
The Kif26a protein-coding gene has been identified as a negative regulator of the GDNF-Ret signaling pathway in enteric neurons. The aim of this study was to investigate the influence of genetic background on the phenotype of Kif26a-deficient (KO, -/-) mice. KO mice with both C57BL/6 and BALB/c genetic backgrounds were established. Survival rates and megacolon development were compared between these two strains of KO mice. Functional bowel assessments and enteric neuron histopathology were perfo ...[more]