Ontology highlight
ABSTRACT:
SUBMITTER: Drieu A
PROVIDER: S-EPMC7101143 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Drieu Antoine A Lanquetin Anastasia A Levard Damien D Glavan Martina M Campos Francisco F Quenault Aurélien A Lemarchand Eloïse E Naveau Mikaël M Pitel Anne Lise AL Castillo José J Vivien Denis D Rubio Marina M
JCI insight 20200227 4
Alcohol abuse is a major public health problem worldwide, causing a wide range of preventable morbidity and mortality. In this translational study, we show that heavy drinking (HD) (≥6 standard drinks/day) is independently associated with a worse outcome for ischemic stroke patients. To study the underlying mechanisms of this deleterious effect of HD, we performed an extensive analysis of the brain inflammatory responses of mice chronically exposed or not to 10% alcohol before and after ischemic ...[more]