Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC7103332 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Zhang Xue X Wu Kailang K Wang Di D Yue Xin X Song Degui D Zhu Ying Y Wu Jianguo J
Virology 20070509 2
High levels of interleukin-6 (IL-6) in the acute stage associated with lung lesions were found in SARS patients. To evaluate the mechanisms behind this event, we investigated the roles of SARS-CoV proteins in the regulation of IL-6. Results showed that the viral nucleocapsid (N) protein activated IL-6 expression in a concentration-dependent manner. Promoter analyses suggested that NF-kappaB binding element was required for IL-6 expression regulated by N protein. Further studies demonstrated that ...[more]