Ontology highlight
ABSTRACT:
SUBMITTER: Qin J
PROVIDER: S-EPMC7104245 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Qin Jiao J Liu Qi Q Liu Zhe Z Pan Yun-Zu YZ Sifuentes-Dominguez Luis L Stepien Karolina P KP Wang Yan Y Tu Yingfeng Y Tan Shuai S Wang Yuan Y Sun Qingxiang Q Mo Xianming X Rizo Josep J Burstein Ezra E Jia Da D
Proceedings of the National Academy of Sciences of the United States of America 20200310 12
Secretagogin (SCGN) is a hexa-EF-hand protein that is highly expressed in the pancreas, brain, and gastrointestinal tract. SCGN is known to modulate regulated exocytosis in multiple cell lines and tissues; however, its exact functions and underlying mechanisms remain unclear. Here, we report that SCGN interacts with the plasma membrane SNARE SNAP-25, but not the assembled SNARE complex, in a Ca<sup>2+</sup>-dependent manner. The crystal structure of SCGN in complex with a SNAP-25 fragment reveal ...[more]