Ontology highlight
ABSTRACT:
SUBMITTER: Nicolet BP
PROVIDER: S-EPMC7104308 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Nicolet Benoît P BP Guislain Aurélie A van Alphen Floris P J FPJ Gomez-Eerland Raquel R Schumacher Ton N M TNM van den Biggelaar Maartje M Wolkers Monika C MC
Proceedings of the National Academy of Sciences of the United States of America 20200311 12
Cytotoxic CD8<sup>+</sup> T cells can effectively kill target cells by producing cytokines, chemokines, and granzymes. Expression of these effector molecules is however highly divergent, and tools that identify and preselect CD8<sup>+</sup> T cells with a cytotoxic expression profile are lacking. Human CD8<sup>+</sup> T cells can be divided into IFN-γ- and IL-2-producing cells. Unbiased transcriptomics and proteomics analysis on cytokine-producing fixed CD8<sup>+</sup> T cells revealed that IL-2 ...[more]