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CD46 is a potent co-stimulatory receptor for expansion of human IFN-?-producing CD8+ T cells.

ABSTRACT: Similar to CD4+ T cells, precursor CD8+ T cells are thought to depend on a co-stimulatory signal through CD28 for proliferation and differentiation into effector cells. CD46 is another co-stimulatory receptor that promotes differentiation of CD4+ T-helper cells type 1 (Th1 cells) into a regulatory phenotype with a switch from IFN-? towards IL-10-secretion over time. Whether CD46 exerts a similar function on CD8+ T cells remains to be fully elucidated. Here, we demonstrate that CD46 co-stimulation induced secretion of IFN-? as well as expansion of IFN-?-secreting CD8+ T cells. In contrast to CD46 co-stimulation of CD4+ T cells, CD8+ T cells did not differentiate into a regulatory IL-10-secreting phenotype. This demonstrates that CD46 is a co-stimulatory receptor on CD8+ T cells, and that it exerts separate functions during CD4+ and CD8+ T-cell differentiation.

SUBMITTER: Hansen AS

PROVIDER: S-EPMC7112827 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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CD46 is a potent co-stimulatory receptor for expansion of human IFN-γ-producing CD8+ T cells.

Hansen Aida S AS Slater Josefine J Biltoft Mette M Bundgaard Bettina B BB Møller Bjarne K BK Höllsberg Per P

Immunology letters 20180611

Similar to CD4+ T cells, precursor CD8+ T cells are thought to depend on a co-stimulatory signal through CD28 for proliferation and differentiation into effector cells. CD46 is another co-stimulatory receptor that promotes differentiation of CD4+ T-helper cells type 1 (Th1 cells) into a regulatory phenotype with a switch from IFN-γ towards IL-10-secretion over time. Whether CD46 exerts a similar function on CD8+ T cells remains to be fully elucidated. ...[more]

PMID: 29902483

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