Ontology highlight
ABSTRACT:
SUBMITTER: Zhan W
PROVIDER: S-EPMC7104388 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Zhan Wenhu W Visone Joseph J Ouellette Tierra T Harris Jacob C JC Wang Rong R Zhang Hao H Singh Pradeep K PK Ginn John J Sukenick George G Wong Tzu-Tshin TT Okoro Judith I JI Scales Ryan M RM Tumwebaze Patrick K PK Rosenthal Philip J PJ Kafsack Björn F C BFC Cooper Roland A RA Meinke Peter T PT Kirkman Laura A LA Lin Gang G
Journal of medicinal chemistry 20190620 13
The <i>Plasmodium</i> proteasome (Pf20S) emerged as a target for antimalarials. Pf20S inhibitors are active at multiple stages of the parasite life cycle and synergize with artemisinins, suggesting that Pf20S inhibitors have potential to be prophylactic, therapeutic, and transmission blocking as well as are useful for combination therapy. We recently reported asparagine ethylenediamines (AsnEDAs) as immunoproteasome inhibitors and modified AsnEDAs as selective Pf20S inhibitors. Here, we report f ...[more]