Ontology highlight
ABSTRACT:
SUBMITTER: Tian K
PROVIDER: S-EPMC7105086 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Tian Kai K Deng Youchao Y Qiu Lin L Zhu Xiangcheng X Shen Ben B Duan Yanwen Y Huang Yong Y
ChemistrySelect 20181129 44
Platensimycin (PTM) is an excellent natural product drug lead against various gram-positive pathogens, including methicillin-resistant <i>Staphylococcus aureus</i> and vancomycin-resistant enterococci. In this study, twenty PTM derivatives with varying aminobenzoic acids were semisynthesized. In contrast to all the previous reported inactive aminobenzaote analogues, a few of them showed moderate antibacterial activities against <i>S. aureus</i>. Our study suggested that modification of the conse ...[more]