Ontology highlight
ABSTRACT:
SUBMITTER: Kim D
PROVIDER: S-EPMC7105105 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Kim Doyoung D Kobayashi Tetsuro T Voisin Benjamin B Jo Jay-Hyun JH Sakamoto Keiko K Jin Seon-Pil SP Kelly Michael M Pasieka Helena B HB Naff Jessica L JL Meyerle Jon H JH Ikpeama Ijeoma D ID Fahle Gary A GA Davis Fred P FP Rosenzweig Sergio D SD Alejo Julie C JC Pittaluga Stefania S Kong Heidi H HH Freeman Alexandra F AF Nagao Keisuke K
Nature medicine 20200120 2
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS) is a potentially fatal multiorgan inflammatory disease associated with herpesvirus reactivation and subsequent onset of autoimmune diseases<sup>1-4</sup>. Pathophysiology remains elusive and therapeutic options are limited. Cases refractory to corticosteroid therapy pose a clinical challenge<sup>1,5</sup> and approximately 30% of patients with DiHS/DRESS develop complications, including infe ...[more]