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The ubiquitous role of ubiquitin in the DNA damage response.

ABSTRACT: Protein ubiquitylation has emerged as an important regulatory mechanism that impacts almost every aspect of the DNA damage response. In this review, we discuss how DNA repair and checkpoint pathways utilize the diversity offered by the ubiquitin conjugation system to modulate the response to genotoxic lesions in space and time. In particular, we will highlight recent work done on the regulation of DNA double-strand breaks signalling and repair by the RNF8/RNF168 E3 ubiquitin ligases, the Fanconi anemia pathway and the role of protein degradation in the enforcement and termination of checkpoint signalling. We also discuss the various functions of deubiquitylating enzymes in these processes along with potential avenues for exploiting the ubiquitin conjugation/deconjugation system for therapeutic purposes.

SUBMITTER: Al-Hakim A

PROVIDER: S-EPMC7105183 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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The ubiquitous role of ubiquitin in the DNA damage response.

Al-Hakim Abdallah A Escribano-Diaz Cristina C Landry Marie-Claude MC O'Donnell Lara L Panier Stephanie S Szilard Rachel K RK Durocher Daniel D

DNA repair 20101104 12

Protein ubiquitylation has emerged as an important regulatory mechanism that impacts almost every aspect of the DNA damage response. In this review, we discuss how DNA repair and checkpoint pathways utilize the diversity offered by the ubiquitin conjugation system to modulate the response to genotoxic lesions in space and time. In particular, we will highlight recent work done on the regulation of DNA double-strand breaks signalling and repair by the RNF8/RNF168 E3 ubiquitin ligases, the Fanconi ...[more]

PMID: 21056014

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Regulation of the DNA damage response by ubiquitin conjugation.

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