Proteomic Analysis of Plasmodium Merosomes: The Link between Liver and Blood Stages in Malaria.
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ABSTRACT:
SUBMITTER: Shears MJ
PROVIDER: S-EPMC7105274 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Proteomic Analysis of <i>Plasmodium</i> Merosomes: The Link between Liver and Blood Stages in Malaria.
Shears Melanie J MJ Sekhar Nirujogi Raja R Swearingen Kristian E KE Renuse Santosh S Mishra Satish S Jaipal Reddy Panga P Moritz Robert L RL Pandey Akhilesh A Sinnis Photini P
Journal of proteome research 20190723 9
The pre-erythrocytic liver stage of the malaria parasite, comprising sporozoites and the liver stages into which they develop, remains one of the least understood parts of the lifecycle, in part owing to the low numbers of parasites. Nonetheless, it is recognized as an important target for antimalarial drugs and vaccines. Here we provide the first proteomic analysis of merosomes, which define the final phase of the liver stage and are responsible for initiating the blood stage of infection. We i ...[more]
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