Ontology highlight
ABSTRACT:
SUBMITTER: Hilal T
PROVIDER: S-EPMC7105340 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Ecancermedicalscience 20200227
The use of small molecule inhibitors in acute myeloid leukaemia (AML) has become ubiquitous with the US Food and Drug Administration approval of multiple agents between 2017 and 2018. Despite the promise, some of these indications are based on early efficacy data (phase I/II), and single-arm studies, and have not been tested in randomised trials. Furthermore, there are important limitations in the evidence that exists in randomised trials. This perspective aims to summarise the data that formed ...[more]