Unknown

Dataset Information

0

Kinetics of viral load and cytokines in severe fever with thrombocytopenia syndrome.


ABSTRACT: BACKGROUND:Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in China, Japan, and Korea, which is characterized by high fever, thrombocytopenia, and high mortality. It is hypothesized that a cytokine storm plays an important role in the pathophysiology of SFTS. However, limited data have been published on the detailed kinetics of the viral load and cytokine profiles throughout the course of this disease. OBJECTIVES:We investigated the patterns of changes in cytokines and viral load in SFTS patients. STUDY DESIGN:During the admission period of patients, RNA was extracted from plasma and quantified by reverse transcription polymerase chain reaction. In addition, cytokine bead arrays were performed for the 18 cytokines and chemokines selected for testing. RESULTS:The median time from admission to the negative conversion of SFTS viremia was 17.0?days. When censored patients were found to be negative for viral load at discharge, the median duration of viral shedding was 13.0?days (95% CI, 5.4-20.6). Interferon (IFN)-?, interleukin (IL)-10, and IFN-?-induced protein (IP)-10 concentrations significantly increased in the early course of disease and then decreased during the hospital stay. However, the concentrations of tumor necrosis factor-?, IL-1?, IL-12p40, IL-13, IL-17A, Regulated on Activation and Normally T-cell Expressed and Secreted (RANTES), and vascular endothelial growth factor (VEGF) increased during the late course of disease. Initial IP-10 levels during hospital days 1-4 were the most significantly correlated with initial viral load (r?=?0.88, P?

SUBMITTER: Kwon JS 

PROVIDER: S-EPMC7106421 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Kinetics of viral load and cytokines in severe fever with thrombocytopenia syndrome.

Kwon Ji-Soo JS   Kim Min-Chul MC   Kim Ji Yeun JY   Jeon Na-Young NY   Ryu Byung-Han BH   Hong Jeongmin J   Kim Min-Jae MJ   Chong Yong Pil YP   Lee Sang-Oh SO   Choi Sang-Ho SH   Kim Yang Soo YS   Woo Jun Hee JH   Kim Sung-Han SH  

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20180131


<h4>Background</h4>Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in China, Japan, and Korea, which is characterized by high fever, thrombocytopenia, and high mortality. It is hypothesized that a cytokine storm plays an important role in the pathophysiology of SFTS. However, limited data have been published on the detailed kinetics of the viral load and cytokine profiles throughout the course of this disease.<h4>Objectives</h4>We investigated the patterns of  ...[more]

Similar Datasets

| S-EPMC9144926 | biostudies-literature
| S-EPMC6700174 | biostudies-literature
| S-EPMC7823500 | biostudies-literature
2022-10-13 | PXD033989 | Pride
| S-EPMC6478219 | biostudies-literature
2024-12-18 | GSE256528 | GEO
| PRJNA1056441 | ENA
| PRJNA1065814 | ENA
| PRJNA732992 | ENA
| S-EPMC7101122 | biostudies-literature