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Human parainfluenza virus circulation, United States, 2011-2019.


ABSTRACT:

Background

Human parainfluenza viruses (HPIVs) cause upper and lower respiratory tract illnesses, most frequently among infants and young children, but also in the elderly. While seasonal patterns of HPIV types 1-3 have been described, less is known about national patterns of HPIV-4 circulation.

Objectives

To describe patterns of HPIVs circulation in the United States (US).

Study design

We used data from the National Respiratory and Enteric Virus Surveillance System (NREVSS), a voluntary passive laboratory-based surveillance system, to characterize the epidemiology and circulation patterns of HPIVs in the US during 2011-2019. We summarized the number of weekly aggregated HPIV detections nationally and by US census region, and used a subset of data submitted to NREVSS from public health laboratories and several clinical laboratories during 2015-2019 to analyze differences in patient demographics.

Results

During July 2011 - June 2019, 2,700,135 HPIV tests were reported; 122,852 (5 %) were positive for any HPIV including 22,446 for HPIV-1 (18 %), 17,474 for HPIV-2 (14 %), 67,649 for HPIV-3 (55 %), and 15,283 for HPIV-4 (13 %). HPIV testing increased substantially each year. The majority of detections occurred in children aged ? 2 years (36 %) with fluctuations in the distribution of age by type.

Conclusions

HPIVs were detected year-round during 2011-2019, with type-specific year-to-year variations in circulation patterns. Among HPIV detections where age was known, the majority were aged ? 2 years. HPIV-4 exhibited an annual fall-winter seasonality, both nationally and regionally. Continued surveillance is needed to better understand national patterns of HPIV circulation.

SUBMITTER: DeGroote NP 

PROVIDER: S-EPMC7106518 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Publications

Human parainfluenza virus circulation, United States, 2011-2019.

DeGroote Nicholas P NP   Haynes Amber K AK   Taylor Calli C   Killerby Marie E ME   Dahl Rebecca M RM   Mustaquim Desiree D   Gerber Susan I SI   Watson John T JT  

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20200109


<h4>Background</h4>Human parainfluenza viruses (HPIVs) cause upper and lower respiratory tract illnesses, most frequently among infants and young children, but also in the elderly. While seasonal patterns of HPIV types 1-3 have been described, less is known about national patterns of HPIV-4 circulation.<h4>Objectives</h4>To describe patterns of HPIVs circulation in the United States (US).<h4>Study design</h4>We used data from the National Respiratory and Enteric Virus Surveillance System (NREVSS  ...[more]

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