Ontology highlight
ABSTRACT:
SUBMITTER: Shaker AMM
PROVIDER: S-EPMC7106896 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Shaker Ahmed M M AMM Abdelall Eman K A EKA Abdellatif Khaled R A KRA Abdel-Rahman Hamdy M HM
BMC chemistry 20200330 1
Three series of 2-(4-methylsulfonylphenyl) indole derivatives have been designed and synthesized. The synthesized compounds were assessed for their antimicrobial, COX inhibitory and anti-inflammatory activities. Compound <b>7g</b> was identified to be the most potent antibacterial candidate against strains of <i>MRSA</i>, <i>E. coli, K. pneumoniae, P. aeruginosa,</i> and <i>A. baumannii</i>, respectively, with safe therapeutic dose. Compounds <b>7a-k, 8a-c,</b> and <b>9a-c</b> showed good anti-i ...[more]