Ontology highlight
ABSTRACT:
SUBMITTER: Huang H
PROVIDER: S-EPMC6393504 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Cell death & disease 20190227 3
Phosphatase and tensin homolog (PTEN) acts as a brake for the phosphatidylinositol 3-kinase-AKT-mTOR complex 1 (mTORC1) pathway, the deletion of which promotes potent central nervous system (CNS) axon regeneration. Previously, we demonstrated that AKT activation is sufficient to promote CNS axon regeneration to a lesser extent than PTEN deletion. It is still questionable whether AKT is entirely responsible for the regenerative effect of PTEN deletion on CNS axons. Here, we show that blocking AKT ...[more]