Troponin structure and function: a view of recent progress.
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ABSTRACT:
SUBMITTER: Marston S
PROVIDER: S-EPMC7109197 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
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Troponin structure and function: a view of recent progress.
Marston Steven S Zamora Juan Eiros JE
Journal of muscle research and cell motility 20190427 1
The molecular mechanism by which Ca<sup>2+</sup> binding and phosphorylation regulate muscle contraction through Troponin is not yet fully understood. Revealing the differences between the relaxed and active structure of cTn, as well as the conformational changes that follow phosphorylation has remained a challenge for structural biologists over the years. Here we review the current understanding of how Ca<sup>2+</sup>, phosphorylation and disease-causing mutations affect the structure and dynam ...[more]
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