Ontology highlight
ABSTRACT:
SUBMITTER: di Caudo C
PROVIDER: S-EPMC7109318 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
di Caudo Carla C Martínez-Valbuena Ivan I Mundiñano Iñaki-Carril IC Gennetier Aurelie A Hernandez Maria M Carmona-Abellan Mar M Marcilla Garcia Irene I Kremer Eric J EJ Luquin Rosario R
Frontiers in molecular neuroscience 20200325
Parkinson's disease is characterized by motor and nonmotor symptoms that gradually appear as a consequence of the selective loss of dopaminergic neurons in the <i>substantia nigra pars compacta</i>. Currently, no treatment can slow Parkinson's disease progression. Inasmuch, there is a need to develop animal models that can be used to understand the pathophysiological mechanisms underlying dopaminergic neuron death. The initial goal of this study was to determine if canine adenovirus type 2 (CAV- ...[more]