Unknown,Transcriptomics,Genomics,Proteomics

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ScRNA-seq of adult Macaca fascicularis brain

ABSTRACT: With improved whole-cell isolation protocols, we performed single-cell RNA sequencing (scRNA-seq) and profiled the transcriptomes from adult non-human primate brain. We identified discriminative cell populations with canonical and novel markers. Cross-species projection demonstrated the evolutionary conservation among mouse, monkey, and human. This dataset serves as a detailed transcriptomic atlas for understanding the adult primate central nervous system.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Macaca fascicularis

SUBMITTER: Zhao-Zhe Hao 

PROVIDER: E-MTAB-10225 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations.

Hao Zhao-Zhe ZZ   Wei Jia-Ru JR   Xiao Dongchang D   Liu Ruifeng R   Xu Nana N   Tang Lei L   Huang Mengyao M   Shen Yuhui Y   Xing Changsheng C   Huang Wanjing W   Liu Xialin X   Xiang Mengqing M   Liu Yizhi Y   Miao Zhichao Z   Liu Sheng S  

Nature neuroscience 20220530 6

The extent to which neurogenesis occurs in adult primates remains controversial. In this study, using an optimized single-cell RNA sequencing pipeline, we profiled 207,785 cells from the adult macaque hippocampus and identified 34 cell populations comprising all major hippocampal cell types. Analysis of their gene expression, specification trajectories and gene regulatory networks revealed the presence of all key neurogenic precursor cell populations, including a heterogeneous pool of radial gli  ...[more]

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