Ontology highlight
ABSTRACT:
SUBMITTER: Mateus R
PROVIDER: S-EPMC7109522 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Mateus Rita R Holtzer Laurent L Seum Carole C Hadjivasiliou Zena Z Dubois Marine M Jülicher Frank F Gonzalez-Gaitan Marcos M
Cell reports 20200301 12
Secreted growth factors can act as morphogens that form spatial concentration gradients in developing organs, thereby controlling growth and patterning. For some morphogens, adaptation of the gradients to tissue size allows morphological patterns to remain proportioned as the organs grow. In the zebrafish pectoral fin, we found that BMP signaling forms a two-dimensional gradient. The length of the gradient scales with tissue length and its amplitude increases with fin size according to a power-l ...[more]