Predicting sub-Golgi localization of type II membrane proteins.

ABSTRACT:

Motivation

Recent research underlines the importance of finegrained knowledge on protein localization. In particular, subcompartmental localization in the Golgi apparatus is important, for example, for the order of reactions performed in glycosylation pathways or the sorting functions of SNAREs, but is currently poorly understood.

Results

We assemble a dataset of type II transmembrane proteins with experimentally determined sub-Golgi localizations and use this information to develop a predictor based on the transmembrane domain of these proteins, making use of a dedicated proteinstructure based kernel in an SVM. Various applications demonstrate the power of our approach. In particular, comparison with a large set of glycan structures illustrates the applicability of our pred

SUBMITTER: van Dijk AD 

PROVIDER: S-EPMC7110242 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature