Ontology highlight
ABSTRACT:
SUBMITTER: Cupovic J
PROVIDER: S-EPMC7111064 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Immunity 20160223 3
Stromal cells generate a complex cellular scaffold that provides specialized microenvironments for lymphocyte activation in secondary lymphoid organs. Here, we assessed whether local activation of stromal cells in the central nervous system (CNS) is mandatory to transfer immune recognition from secondary lymphoid organs into the infected tissue. We report that neurotropic virus infection in mice triggered the establishment of such stromal cell niches in the CNS. CNS stromal cell activation was d ...[more]