Ontology highlight
ABSTRACT:
SUBMITTER: Grebe KM
PROVIDER: S-EPMC2664017 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Grebe Kristie M KM Hickman Heather D HD Irvine Kari R KR Takeda Kazuyo K Bennink Jack R JR Yewdell Jonathan W JW
Proceedings of the National Academy of Sciences of the United States of America 20090313 13
Despite the longstanding appreciation of communication between the nervous and the immune systems, the nature and significance of these interactions to immunity remain enigmatic. Here, we show that 6-hydroxydopamine-mediated ablation of the mouse peripheral sympathetic nervous system increases primary CD8(+) T cell responses to viral and cellular antigens presented by direct priming or cross-priming. The sympathetic nervous system also suppresses antiviral CD4(+) T cell responses, but this is no ...[more]