Molecular Evolution of Human Coronavirus Genomes.
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ABSTRACT:
SUBMITTER: Forni D
PROVIDER: S-EPMC7111218 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Molecular Evolution of Human Coronavirus Genomes.
Forni Diego D Cagliani Rachele R Clerici Mario M Sironi Manuela M
Trends in microbiology 20161019 1
Human coronaviruses (HCoVs), including SARS-CoV and MERS-CoV, are zoonotic pathogens that originated in wild animals. HCoVs have large genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ in number and sequence even among closely related CoVs. Thus, in addition to recombination and mutation, HCoV genomes evolve through gene gains and losses. In this review we summarize recent findings on the molecular evolution of HC ...[more]
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