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Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases.

ABSTRACT: A series of sialosides modified at the 4- and 9-hydroxy group were synthesised and tested for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses. While no inhibition of the sialate-4-O-acetylesterases from mouse hepatitis virus strain S or sialodacryoadenitis virus was found, a 9-O-methyl derivative displayed inhibitory activity against recombinant sialate-9-O-acetylesterase from influenza C virus.

SUBMITTER: Stanley M

PROVIDER: S-EPMC7111470 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases.

Stanley Mathew M Mayr Juliane J Huber Wolfgang W Vlasak Reinhard R Streicher Hansjörg H

European journal of medicinal chemistry 20110408 7

A series of sialosides modified at the 4- and 9-hydroxy group were synthesised and tested for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses. While no inhibition of the sialate-4-O-acetylesterases from mouse hepatitis virus strain S or sialodacryoadenitis virus was found, a 9-O-methyl derivative displayed inhibitory activity against recombinant sialate-9-O-acetylesterase from influenza C virus. ...[more]

PMID: 21524502

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