Identification and formation mechanism of a novel noncoding RNA produced by avian infectious bronchitis virus.
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ABSTRACT:
SUBMITTER: An H
PROVIDER: S-EPMC7112027 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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Identification and formation mechanism of a novel noncoding RNA produced by avian infectious bronchitis virus.
An Hongliu H Cai Zhichao Z Yang Yuying Y Wang Zhaoxiong Z Liu Ding Xiang DX Fang Shouguo S
Virology 20190105
Viral noncoding (nc) RNAs have been shown to play important roles in viral life cycle. Many viruses employ different mechanism to produce ncRNAs. Here, we report that coronavirus infectious bronchitis virus (IBV) produces a novel ncRNA in virus-infected cells. This ncRNA consists of 563 nucleotides excluding a poly(A) tail, is mainly derived from the 3'-untranslated region of IBV genome, and contains a 63-nt-long of terminal leader sequence derived from the 5' end of the viral genome. Using muta ...[more]
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