Ontology highlight
ABSTRACT:
SUBMITTER: Kwock JT
PROVIDER: S-EPMC7112749 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Kwock Jeffery T JT Handfield Chelsea C Suwanpradid Jutamas J Hoang Peter P McFadden Michael J MJ Labagnara Kevin F KF Floyd Lauren L Shannon Jessica J Uppala Ranjitha R Sarkar Mrinal K MK Gudjonsson Johann E JE Corcoran David L DL Lazear Helen M HM Sempowski Gregory G Horner Stacy M SM MacLeod Amanda S AS
Science advances 20200401 14
In the skin, antiviral proteins and other immune molecules serve as the first line of innate antiviral defense. Here, we identify and characterize the induction of cutaneous innate antiviral proteins in response to IL-27 and its functional role during cutaneous defense against Zika virus infection. Transcriptional and phenotypic profiling of epidermal keratinocytes treated with IL-27 demonstrated activation of antiviral proteins OAS1, OAS2, OASL, and MX1 in the skin of both mice and humans. IL-2 ...[more]