Dataset Information

Novel activities of safe-in-human broad-spectrum antiviral agents.

ABSTRACT: According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-in-human antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we reviewed all approved, investigational and experimental antiviral agents, which are safe in man, and identified 59 compounds that target at least three viral diseases. We tested 55 of these compounds against eight different RNA and DNA viruses. We found novel activities for dalbavancin against echovirus 1, ezetimibe against human immunodeficiency virus 1 and Zika virus, as well as azacitidine, cyclosporine, minocycline, oritavancin and ritonavir against Rift valley fever virus. Thus, the spectrum of antiviral activities of existing antiviral agents could be expanded towards other viral diseases.

SUBMITTER: Ianevski A

PROVIDER: S-EPMC7113852 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Novel activities of safe-in-human broad-spectrum antiviral agents.

Ianevski Aleksandr A Zusinaite Eva E Kuivanen Suvi S Strand Mårten M Lysvand Hilde H Teppor Mona M Kakkola Laura L Paavilainen Henrik H Laajala Mira M Kallio-Kokko Hannimari H Valkonen Miia M Kantele Anu A Telling Kaidi K Lutsar Irja I Letjuka Pille P Metelitsa Natalja N Oksenych Valentyn V Bjørås Magnar M Nordbø Svein Arne SA Dumpis Uga U Vitkauskiene Astra A Öhrmalm Christina C Bondeson Kåre K Bergqvist Anders A Aittokallio Tero T Cox Rebecca J RJ Evander Magnus M Hukkanen Veijo V Marjomaki Varpu V Julkunen Ilkka I Vapalahti Olli O Tenson Tanel T Merits Andres A Kainov Denis D

Antiviral research 20180423

According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-in-human antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we reviewed all approved, investigational and experimental antiviral agents, which are safe in man, and identified 59 compounds that target at least three viral diseases. We tested 55 of these compounds against eight different RNA and DNA viruses. We found novel activities for ...[more]

PMID: 29698664

Dataset Information

Novel activities of safe-in-human broad-spectrum antiviral agents.

Publications

Novel activities of safe-in-human broad-spectrum antiviral agents.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Similar Datasets

Discovery and development of safe-in-man broad-spectrum antiviral agents.
| S-EPMC7128205 | biostudies-literature

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.
| S-EPMC4868442 | biostudies-literature

A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses.
| S-EPMC4766503 | biostudies-literature

Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents.
| S-EPMC9123807 | biostudies-literature

Broad-Spectrum Antiviral Agents Based on Multivalent Inhibitors of Viral Infectivity.
| S-EPMC7995163 | biostudies-literature

Clofazimine derivatives as potent broad-spectrum antiviral agents with dual-target mechanism.
| S-EPMC8897968 | biostudies-literature

GSK983: a novel compound with broad-spectrum antiviral activity.
| S-EPMC7114156 | biostudies-literature

Broad-spectrum antiviral therapeutics.
| S-EPMC3144912 | biostudies-literature

The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition.
| S-EPMC4441479 | biostudies-literature

Synthesis and antiviral activities of methylenecyclopropane analogs with 6-alkoxy and 6-alkylthio substitutions that exhibit broad-spectrum antiviral activity against human herpesviruses.
| S-EPMC3719742 | biostudies-literature