Ontology highlight
ABSTRACT:
SUBMITTER: Hraber P
PROVIDER: S-EPMC7114124 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Trends in biotechnology 20190816 1
Viral proteins evade host immune function by molecular mimicry, often achieved by short linear motifs (SLiMs) of three to ten consecutive amino acids (AAs). Motif mimicry tolerates mutations, evolves quickly to modify interactions with the host, and enables modular interactions with protein complexes. Host cells cannot easily coordinate changes to conserved motif recognition and binding interfaces under selective pressure to maintain critical signaling pathways. SLiMs offer potential for use in ...[more]