Ontology highlight
ABSTRACT:
SUBMITTER: Tamm T
PROVIDER: S-EPMC7114514 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Tamm Tiina T Suurväli Jaanus J Lucchesi Jimmy J Olspert Allan A Truve Erkki E
Virus research 20090911 1-2
The -1 programmed ribosomal frameshifting (-1 PRF) mechanism utilized by many viruses is dependent on a heptanucleotide slippery sequence and a downstream secondary structure element. In the current study, the RNA structure downstream from the slippery site of cocksfoot mottle sobemovirus (CfMV) was proven to be a 12bp stem-loop with a single bulge and a tetranucleotide loop. Several deletion and insertion mutants with altered stem-loop structures were tested in wheat germ extract (WGE) for fram ...[more]