Ontology highlight
ABSTRACT:
SUBMITTER: Briand N
PROVIDER: S-EPMC7114793 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Briand Nolwenn N Collas Philippe P
Genome biology 20200402 1
At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-associated domains (LADs) aid functional organization of the genome. We review the organization of LADs and provide evidence of LAD heterogeneity from cell ensemble and single-cell data. LADs are typically repressive environments in the genome; nonetheless, we discuss findings of lamin interactions with regulatory elements of active genes, and the role lamins may play in genome regulation. We address the r ...[more]