Unknown

Dataset Information

0

Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.

ABSTRACT: One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of quinoline with pyrimidine have been synthesized and evaluated for their antiplasmodial activity against both CQ(S) and CQ(R) strains of Plasmodium falciparum. These depicted activity in nanomolar range and were found to bind to heme as well as AT rich pUC18 DNA.

SUBMITTER: Singh K 

PROVIDER: S-EPMC7115683 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.

Singh Kamaljit K   Kaur Hardeep H   Chibale Kelly K   Balzarini Jan J  

European journal of medicinal chemistry 20130610

One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of quinoline with pyrimidine have been synthesized and evaluated for their antiplasmodial activity against both CQ(S) and CQ(R) strains of Plasmodium falciparum. These depicted activity in nanomolar range and were found to bind to heme as well as  ...[more]

Similar Datasets

Unknown Synthesis, Antibacterial Activities, Mode of Action and Acute Toxicity Studies of New Oxazolidinone-Fluoroquinolone Hybrids.
| S-EPMC6514978 | biostudies-literature
Unknown 2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
| S-EPMC7115513 | biostudies-literature
Unknown Antimalarials with Benzothiophene Moieties as Aminoquinoline Partners.
| S-EPMC6155332 | biostudies-literature
Unknown Novel 4-aminoquinoline-pyrimidine based hybrids with improved in vitro and in vivo antimalarial activity.
| S-EPMC4025768 | biostudies-literature
Unknown Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics.
| S-EPMC7317206 | biostudies-literature
Unknown Insights into the mode of action of novel fluoroketolides, potent inhibitors of bacterial protein synthesis.
| S-EPMC3910732 | biostudies-literature
Unknown Design and Synthesis of New Pyrimidine-Quinolone Hybrids as Novel hLDHA Inhibitors
| S-EPMC9322123 | biostudies-literature
Unknown 1,4-Naphthoquinone Analogues: Potent Antibacterial Agents and Mode of Action Evaluation.
| S-EPMC6480589 | biostudies-literature
Transcriptomics Mode of action studies of the novel bisquaternary bisnaphthalimide MT02 against Staphylococcus aureus
2011-01-04 | E-GEOD-23077 | biostudies-arrayexpress
Unknown Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents.
| S-EPMC6225336 | biostudies-literature