Ontology highlight
ABSTRACT:
SUBMITTER: Singh K
PROVIDER: S-EPMC7115683 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20130610
One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of quinoline with pyrimidine have been synthesized and evaluated for their antiplasmodial activity against both CQ(S) and CQ(R) strains of Plasmodium falciparum. These depicted activity in nanomolar range and were found to bind to heme as well as ...[more]