Ontology highlight
ABSTRACT:
SUBMITTER: Rupprecht A
PROVIDER: S-EPMC7115858 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Rupprecht Anne A Moldzio Rudolf R Mödl Bernadette B Pohl Elena E EE
Biochimica et biophysica acta. Bioenergetics 20190315 5
Mitochondrial uncoupling protein 2 (UCP2) is highly abundant in rapidly proliferating cells that utilize aerobic glycolysis, such as stem cells, cancer cells, and cells of the immune system. However, the function of UCP2 has been a longstanding conundrum. Considering the strict regulation and unusually short life time of the protein, we propose that UCP2 acts as a "signaling protein" under nutrient shortage in cancer cells. We reveal that glutamine shortage induces the rapid and reversible downr ...[more]