Ontology highlight
ABSTRACT:
SUBMITTER: Malsam J
PROVIDER: S-EPMC7116205 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Cell reports 20200701 3
The neuronal protein complexin contains multiple domains that exert clamping and facilitatory functions to tune spontaneous and action potential-triggered synaptic release. We address the clamping mechanism and show that the accessory helix of complexin arrests assembly of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex that forms the core machinery of intracellular membrane fusion. In a reconstituted fusion assay, site- and stage-specific photo-cross-li ...[more]