Ontology highlight
ABSTRACT:
SUBMITTER: Berghoff SA
PROVIDER: S-EPMC7116742 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Berghoff Stefan A SA Spieth Lena L Sun Ting T Hosang Leon L Schlaphoff Lennart L Depp Constanze C Düking Tim T Winchenbach Jan J Neuber Jonathan J Ewers David D Scholz Patricia P van der Meer Franziska F Cantuti-Castelvetri Ludovico L Sasmita Andrew O AO Meschkat Martin M Ruhwedel Torben T Möbius Wiebke W Sankowski Roman R Prinz Marco M Huitinga Inge I Sereda Michael W MW Odoardi Francesca F Ischebeck Till T Simons Mikael M Stadelmann-Nessler Christine C Edgar Julia M JM Nave Klaus-Armin KA Saher Gesine G
Nature neuroscience 20201221 1
The repair of inflamed, demyelinated lesions as in multiple sclerosis (MS) necessitates the clearance of cholesterol-rich myelin debris by microglia/macrophages and the switch from a pro-inflammatory to an anti-inflammatory lesion environment. Subsequently, oligodendrocytes increase cholesterol levels as a prerequisite for synthesizing new myelin membranes. We hypothesized that lesion resolution is regulated by the fate of cholesterol from damaged myelin and oligodendroglial sterol synthesis. By ...[more]