Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez GA
PROVIDER: S-EPMC4995517 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Gonzalez Ginez A GA Hofer Matthias P MP Syed Yasir A YA Amaral Ana I AI Rundle Jon J Rahman Saifur S Zhao Chao C Kotter Mark R N MRN
Scientific reports 20160824
Enhancing central nervous system (CNS) myelin regeneration is recognized as an important strategy to ameliorate the devastating consequences of demyelinating diseases such as multiple sclerosis. Previous findings have indicated that myelin proteins, which accumulate following demyelination, inhibit remyelination by blocking the differentiation of rat oligodendrocyte progenitor cells (OPCs) via modulation of PKCα. We therefore screened drugs for their potential to overcome this differentiation bl ...[more]