Ontology highlight
ABSTRACT:
SUBMITTER: Hill L
PROVIDER: S-EPMC7116900 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Hill Louisa L Ebert Anja A Jaritz Markus M Wutz Gordana G Nagasaka Kota K Tagoh Hiromi H Kostanova-Poliakova Daniela D Schindler Karina K Sun Qiong Q Bönelt Peter P Fischer Maria M Peters Jan-Michael JM Busslinger Meinrad M
Nature 20200701 7819
Nuclear processes, such as V(D)J recombination, are orchestrated by the three-dimensional organization of chromosomes at multiple levels, including compartments<sup>1</sup> and topologically associated domains (TADs)<sup>2,3</sup> consisting of chromatin loops<sup>4</sup>. TADs are formed by chromatin-loop extrusion<sup>5-7</sup>, which depends on the loop-extrusion function of the ring-shaped cohesin complex<sup>8-12</sup>. Conversely, the cohesin-release factor Wapl<sup>13,14</sup> restricts l ...[more]