Ontology highlight
ABSTRACT:
SUBMITTER: Wong SL
PROVIDER: S-EPMC7117541 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Wong S L Alan SL Chen Yiwei Y Chan Chak Ming CM Chan C S Michael CS Chan Paul K S PK Chui Y L YL Fung Kwok Pui KP Waye Mary M Y MM Tsui Stephen K W SK Chan H Y Edwin HY
Biochemical and biophysical research communications 20050926 2
The Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3a locus encodes a 274 a.a. novel protein, and its expression has been confirmed in SARS patients. To study functional roles of 3a, we established a transgenic fly model for the SARS-CoV 3a gene. Misexpression of 3a in Drosophila caused a dominant rough eye phenotype. Using a specific monoclonal antibody, we demonstrated that the 3a protein displayed a punctate cytoplasmic localization in Drosophila as in SARS-CoV-infected cells. We pr ...[more]