Ontology highlight
ABSTRACT:
SUBMITTER: Gordon RA
PROVIDER: S-EPMC7122749 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Gordon Rachael A RA Tilstra Jeremy S JS Marinov Anthony A Nickerson Kevin M KM Bastacky Sheldon I SI Shlomchik Mark J MJ
PloS one 20200403 4
Loss of tolerance to nuclear antigens and multisystem tissue destruction is a hallmark of systemic lupus erythematosus (SLE). Although the source of autoantigen in lupus remains elusive, a compelling hypothetical source is dead cell debris that drives autoimmune activation. Prior reports suggest that neutrophil extracellular traps (NETs) and their associated death pathway, NETosis, are sources of autoantigen in SLE. However, others and we have shown that inhibition of NETs by targeting the NADPH ...[more]