Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC7124937 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Science advances 20200403 14
Patterned cell divisions require a precisely oriented spindle that segregates chromosomes and determines the cytokinetic plane. In this study, we investigated how the meiotic spindle orients through an obligatory rotation during meiotic division in mouse oocytes. We show that spindle rotation occurs at the completion of chromosome segregation, whereby the separated chromosome clusters each define a cortical actomyosin domain that produces cytoplasmic streaming, resulting in hydrodynamic forces o ...[more]