Ontology highlight
ABSTRACT:
SUBMITTER: Yi K
PROVIDER: S-EPMC3587830 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Yi Kexi K Rubinstein Boris B Unruh Jay R JR Guo Fengli F Slaughter Brian D BD Li Rong R
The Journal of cell biology 20130225 5
Polar body extrusion during oocyte maturation is critically dependent on asymmetric positioning of the meiotic spindle, which is established through migration of the meiosis I (MI) spindle/chromosomes from the oocyte interior to a subcortical location. In this study, we show that MI chromosome migration is biphasic and driven by consecutive actin-based pushing forces regulated by two actin nucleators, Fmn2, a formin family protein, and the Arp2/3 complex. Fmn2 was recruited to endoplasmic reticu ...[more]