Ontology highlight
ABSTRACT:
SUBMITTER: Nelson CA
PROVIDER: S-EPMC7125549 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20050101 1
The open reading frame (ORF) 7a of the SARS-associated coronavirus (SARS-CoV) encodes a unique type I transmembrane protein of unknown function. We have determined the 1.8 A resolution crystal structure of the N-terminal ectodomain of orf7a, revealing a compact seven-stranded beta sandwich unexpectedly similar in fold and topology to members of the Ig superfamily. We also demonstrate that, in SARS-CoV- infected cells, the orf7a protein is expressed and retained intracellularly. Confocal microsco ...[more]