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Biosynthesis of anti-HCV compounds using thermophilic microorganisms.


ABSTRACT: This work describes the application of thermophilic microorganisms for obtaining 6-halogenated purine nucleosides. Biosynthesis of 6-chloropurine-2'-deoxyriboside and 6-chloropurine riboside was achieved by Geobacillus stearothermophilus CECT 43 with a conversion of 90% and 68%, respectively. Furthermore, the selected microorganism was satisfactorily stabilized by immobilization in an agarose matrix. This biocatalyst can be reused at least 70 times without significant loss of activity, obtaining 379mg/L of 6-chloropurine-2'-deoxyriboside. The obtained compounds can be used as antiviral agents.

SUBMITTER: Rivero CW 

PROVIDER: S-EPMC7125738 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Biosynthesis of anti-HCV compounds using thermophilic microorganisms.

Rivero Cintia W CW   De Benedetti Eliana C EC   Sambeth Jorge E JE   Lozano Mario E ME   Trelles Jorge A JA  

Bioorganic & medicinal chemistry letters 20120821 19


This work describes the application of thermophilic microorganisms for obtaining 6-halogenated purine nucleosides. Biosynthesis of 6-chloropurine-2'-deoxyriboside and 6-chloropurine riboside was achieved by Geobacillus stearothermophilus CECT 43 with a conversion of 90% and 68%, respectively. Furthermore, the selected microorganism was satisfactorily stabilized by immobilization in an agarose matrix. This biocatalyst can be reused at least 70 times without significant loss of activity, obtaining  ...[more]

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