Biosynthesis of anti-HCV compounds using thermophilic microorganisms.
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ABSTRACT:
SUBMITTER: Rivero CW
PROVIDER: S-EPMC7125738 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Biosynthesis of anti-HCV compounds using thermophilic microorganisms.
Rivero Cintia W CW De Benedetti Eliana C EC Sambeth Jorge E JE Lozano Mario E ME Trelles Jorge A JA
Bioorganic & medicinal chemistry letters 20120821 19
This work describes the application of thermophilic microorganisms for obtaining 6-halogenated purine nucleosides. Biosynthesis of 6-chloropurine-2'-deoxyriboside and 6-chloropurine riboside was achieved by Geobacillus stearothermophilus CECT 43 with a conversion of 90% and 68%, respectively. Furthermore, the selected microorganism was satisfactorily stabilized by immobilization in an agarose matrix. This biocatalyst can be reused at least 70 times without significant loss of activity, obtaining ...[more]
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